The morbidity of tick‐borne encephalitis (TBE) varies yearly by as much as 10‐fold among the people of Western Siberia. This long‐term variation is dependent on many factors such as the density of the tick populations, the prevalence of TBE virus (TBEV) among sub‐adult ticks, the yearly virulence of the TBEV, and prophylactic measures. Here we highlight the role of small mammal hosts in the circulation of TBEV through the ecosystem. Refining classical models of non‐viremic horizontal transmission, we emphasize the recently (...) understood fact that the physiological and immunological status of the small mammal hosts affects the tick and virus‐host interactions. In addition to its theoretical interest, our approach may lead to some practical improvements in the precision of epidemiological forecasts and perhaps in forestalling the severity of outbreaks of TBE, or, at least, in forewarning medical authorities and the general public of impending TBE outbreaks. (shrink)

The possible existence of extraterrestrials has provoked more than five centuries of theological speculation on how these beings, if they exist, relate to God. A certain stream of thought present in these debates argues that the eventual discovery of aliens would obligate human Christians to evangelize them for the salvation of their souls. Current research into humanity's prehistory suggests that, if this ever actually happens, it will have been partially facilitated by humanity's remarkable capacity for interspecies empathy—an ability that seems (...) to be genetic in nature and which stems from our species' ancient experience with dogs. In light of the above, recommendations are made concerning future potential exomissionary screening criteria and a concluding section touches on the role of animals in God's work. (shrink)

The author explores various pedagogical methods concerning how to teach Wittgenstein’s later work. A significant obstacle for the incorporation of Wittgenstein into an undergraduate curriculum is to decipher the major features of his philosophical ideas. The engagement with Wittgenstein’s work is not a task of mere comprehension or thought, but rather of discernment and observation of the ways language operates in the formulation of ideas. The distinction between observation and thought in Wittgenstein’s work on language is often overlooked. In order (...) to teach Wittgenstein effectively, the curriculum should focus on various methods to teach students not just to think but to observe. The author offers a series of classroom exercises and games to engage students with the text and to elucidate philosophical components necessary to understand the author. The games direct students’ attention to what they need to notice and observe in the function of language in Wittgenstein’s later work. (shrink)

This article is a critique of the failure of Wagner's Der Ring des Nibelungen. It considers this as a metaphysical problem rather than an aesthetic or formal one. The article, considering Wagner’s inheritance from Haydn, claims him as the first composer of the culture industry. This will lead the author to conclusions regarding a gendered Das Unheimlich, the distinction between technology and technique, and the philosophy of aesthetics.

This book distinguishes itself in its integrated approach towards scientific research, and studies the basics of the methodology of scientific research and the organization of scientific activity from the viewpoint of systems science and system analysis. The book discusses the basics of the methodology including philosophical, psychological, epistemological and ethical/aesthetical foundations, the characteristics of scientific activity, including principles of scientific cognition, the means and methods of scientific research, the organization of a research implementation process and its chronological structure and finally, (...) the organization of a collective scientific research design. (shrink)

Scale-free network models describe many natural and social phenomena. In particular, networks of interacting components of a living cell were shown to possess scale-free properties. A recent study(1) compares the system-level properties of metabolic and information networks in 43 archaeal, bacterial and eukaryal species and claims that the scale-free organization of these networks is more conserved during evolution than their content. BioEssays 24:105–109, 2002. Published 2002 Wiley Periodicals, Inc.

Our first aim is to make the study of informal notions of proof plausible. Put differently, since the raison d'étre of anything like existing proof theory seems to rest on such notions, the aim is nothing else but to make a case for proof theory; ...

This crucial volume contains a newly-edited cache of over thirty essays on a diverse range of topics from the renowned philosopher, Adam Ferguson, a leading figure of the Scottish Enlightenment. Following on from The Correspondence of Adam Ferguson, this collection aims to set the essays more fully in the history of western philosophy, to which they made an important contribution. They give an exhaustive picture of the thinking of the author and expound ideas which build on and extend the originality (...) of his earlier work. The need for systematic writing in his earlier, published work inevitably marginalized the topics of interest that Ferguson would resume in the leisure of his retirement, when he was free to rethink and clarify earlier problems. Long-unpulished, his later essays represent a re-appraisal of the philosophical, historical and anthropoligical themes that he had examined before. In this authoritative edition, Ferguson's views on disparate philosophical, anthropological and historical topics can at last be viewed in one impressive volume. His texts are transcribed as faithfully as possible and are accompanied by extensive introductions from the general editor and both contributing editors. (shrink)

Background: Patients undergoing invasive neurosurgical procedures offer researchers unique opportunities to study the brain. Deep brain stimulation patients, for example, may participate in research during the surgical implantation of the stimulator device. Although this research raises many ethical concerns, little attention has been paid to basic studies, which offer no therapeutic benefits, and the value of patient-participant perspectives.Methods: Semi-structured interviews were conducted with fourteen individuals across two studies who participated in basic intraoperative research during their deep brain stimulator surgery. Interviews (...) explored interpretations of risks and benefits, enrollment motivations, and experiences of participating in awake brain research. Reflexive thematic analysis was conducted.Results: Seven themes were identified from participant narratives, including robust attitudes of trust, high valuations of basic science research, impacts of the surgical context, and mixed experiences of participation.Conclusion: We argue that these narratives raise the potential for a translational misconception and motivate intraoperative re-consent procedures. (shrink)